Thermo Scientific AppsLab Library: AU72648: Determination of Gentamicin and Related Impurities in Gentamicin Sulfate using Simple Eluents (Part B)

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AU72648: Determination of Gentamicin and Related Impurities in Gentamicin Sulfate using Simple Eluents (Part B) Be the first to rate this application

Description

This application update demonstrates that gentamicin sulfate and related impurities can be separated quickly compared to the method in the United States Pharmacopeia (USP) Gentamicin Sulfate monograph using a Dionex IonPac AmG-3µm C18 column with 100 mM TFA (trifluoroacetic acid) with 2% acetonitrile as the eluent . (Method B in AU 72648)). This method meets or exceeds the performance criteria for Content of Gentamicins in the USP Gentamicin Sulfate monograph.

Market:	Pharma
Keywords:	aminoglycoside, Antibiotic, Drug Substance, Electrochemical detection, USP, PAD, Dionex ICS 5000+ HPIC system, Dionex ICS-6000, Dionex IonPac AmG-3µm C18 column, EP, ion pair reversed phase HPLC
Matrix:	Water
Author:	Jingli Hu and Jeff Rohrer
Affiliation:	Thermo Fisher Scientific

Uploaded on 4/23/2018.

For Research Use Only. Not for use in diagnostic procedures.