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AN72647: Determination of Gentamicin and Related Impurities in Gentamicin Sulfate
Description
This application note demonstrates that the USP Gentamicin Sulfate monograph Content of Gentamicins method and the USP in-process revision Gentamicin Sulfate monograph method for organic impurities method can be successfully executed with a Dionex IonPac AmG-3µm C18 column using either the 4- or 3-potential carbohydrate waveform. The separation, linearity, reproducibility, and sensitivity were found to meet or exceed the current USP/EP Gentamicin Sulfate monograph performance requirements. This method is reliable and can be used for the routine monitoring of gentamicin.| Market: | Pharma |
| Keywords: | aminoglycoside, Antibiotic, Drug Substance, Electrochemical detection, USP, PAD, Dionex ICS 5000+ HPIC system, Dionex ICS-6000, Dionex IonPac AmG-3µm C18 column, EP, ion pair reversed phase HPLC |
| Matrix: | Water |
| Author: | Jingli Hu and Jeffrey Rohrer |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
