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AN72649: Validation of an Improved Ion Chromatography Method for the Limit of Choline Test in the USP Succinylcholine Chloride Monograph Be the first to rate this application


Succinylcholine chloride is an approved intravenous (IV) medication used as a skeletal muscle relaxant during procedures of short duration. Choline Chloride is an impurity. An improved ion chromatography (IC) method is proposed for the limit of choline test in the USP Succinylcholine Chloride monograph. A Thermo Scientific Dionex IC system with a Thermo Scientific Dionex IonPac CS19 anion-exchange column and suppressed conductivity detection were used for the method. This application note reports the method development and evaluation.
Market: Pharma
Keywords: Dionex IonPac CS19 Column, Drug Substance, ICS-5000+, Pharmaceutical, Impurity, suppressed conductivity detection, ICS-6000, drug product, United States Pharmacopeia, USP monograph
Matrix: drug and drug product
Author: Hua Yang and Jeffrey Rohrer
Affiliation: Thermo Fisher Scientific
Uploaded on 3/23/2018.

For Research Use Only. Not for use in diagnostic procedures.