Thermo Scientific AppsLab Library: AN72502: Assay of Sodium Thiosulfate and Ionic Impurities in Sodium Thiosulfate Using Ion Chromatography- (Part 2-Impurities)

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AN72502: Assay of Sodium Thiosulfate and Ionic Impurities in Sodium Thiosulfate Using Ion Chromatography- (Part 2-Impurities) Be the first to rate this application

Description

Sodium thiosulfate is approved for the treatment of acute cyanide poisoning. An ion chromatography (IC) method has been proposed to replace existing titration-based assays in the Sodium Thiosulfate and its Injection monographs. Another IC method has also been proposed for determining impurities. This application note evaluates both methods following the USP guidelines (<1225>, Validation of Compendial Methods). A Dionex ICS-5000+ IC system with a Dionex IonPac AS12A column and suppressed conductivity detection were used for both method evaluations. An ICS-6000 can be used for this application.

Market:	Pharma
Keywords:	Drug Substance, ICS-5000+, Pharmaceutical, USP monograph, Sulfite, Impurity, Chloride, Sulfate, suppressed conductivity detection, Drug Product, Dionex IonPac AS12A Column, Sodium thiosulfate, <1225>, United States Pharmacopeia, ICS-6000
Matrix:	Drug product, Drug substance, Sodium Thiosulfate
Author:	Hua Yang and Jeffrey Rohrer
Affiliation:	Thermo Fisher Scientific, Sunnyvale, CA USA

Uploaded on 11/22/2017.

For Research Use Only. Not for use in diagnostic procedures.